Acetic Acid → HCID 20381778, compound

HRID 1833397Notes

Reaction equation

HRID 1833397 reaction equation
C[O:2][C:3]([C:5]1[NH:6][C:7]2[C:12]([C:13]=1[O:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[NH2:21])=[CH:11][CH:10]=[CH:9][CH:8]=2)=[O:4].O.C(O)(=O)C>C(O)C>[NH2:21][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[O:14][C:13]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][C:5]=1[C:3]([OH:4])=[O:2]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 962WaterHCID 54161447HCID 54161447, compound

Product 1

HCID 20381778HCID 20381778, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.6g of methyl-3-[o-aminophenoxy]-indole-2-carboxylate was dissolved in 10ml each of ethanol and water and refluxed for 10 min. The clear solution was acidified with acetic acid. The white precipitate was filtered and recrystallized from acetonitrile to give analytical material, mp. 217°-18°.

Workup

  1. filtrationThe white precipitate was filtered
  2. customrecrystallized from acetonitrile
  3. customto give analytical material, mp. 217°-18°

Sources & evidence

ORD record
ord-6ec7ff83f3164de28c2deb0448fa45a7
Source dataset
uspto-grants-1978_01
Patent number
US04066660

Reaction notes

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