2-Ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline → HCID 54128793, compound

HRID 1833400Notes

Reaction equation

HRID 1833400 reaction equation
[NH2:1][C:2]1[CH:21]=[CH:20][CH:19]=[CH:18][C:3]=1[O:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[N:7](C)[C:6]=1[C:15](O)=[O:16].[CH3:22]COC1N(C(OCC)=O)C2C(=CC=CC=2)C=C1>C(#N)C>[CH3:22][N:1]1[C:2]2[CH:21]=[CH:20][CH:19]=[CH:18][C:3]=2[O:4][C:5]2[C:13]3[C:8]([NH:7][C:6]=2[C:15]1=[O:16])=[CH:9][CH:10]=[CH:11][CH:12]=3

Participants

4

Reactant 2

HCID 278332-Ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinolineHCID 20381755HCID 20381755, compound

Product 1

HCID 54128793HCID 54128793, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

In the same way as described in example 4, 3-[o-aminophenoxy]-1-methyl-indole-2-carboxylic acid was cyclized with EEDQ. Analytical material was obtained by recrystallization from acetonitrile, mp. 247°-8°.

Sources & evidence

ORD record
ord-04541c62b9574434a8b10c7736debcea
Source dataset
uspto-grants-1978_01
Patent number
US04066660

Reaction notes

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