Tetrahydrofuran → HCID 20381779, compound

Participants

Reaction Steps

A mixture of 1.8g of 7-methyl-7H-indolo [3,2-b][1,5]benzoxazepin-6(5H)-one, 0.42g of 57% sodium hydride-mineral oil dispersion and 10ml of THF was refluxed for 15 min. and then treated with 4.0g of 3-chloropropylpiperidine. The mixture was refluxed for 24 hrs., diluted with 2N HCl and extracted with ether. The aqueous layer was made basic with 5% NaOH and the oil extracted with ether. The ether phase was dried and treated with dry HCl to give a white solid. The solid was recrystallized from methanol-ether to give analytical material, mp. 205°-6°.

Provenance & Evidence