反应详情

A mixture of methyl 8-methylsulfonyl-12-acetoxy-13-(3-trifluoromethylphenoxy)tridecanoate (9.90 g., 0.019 mole), 20% aqueous sodium hydroxide (30 ml.) and methanol (30 ml.) is stirred at room temperature overnight. Then the reaction mixture is concentrated in vacuo on a steam bath. The concentrate is dissolved in water and extracted with ether. The basic aqueous solution is acidified with 6N hydrochloric acid and extracted with ether. These ether extracts are washed with water until neutral, dried over anhydrous magnesium sulfate and concentrated in vacuo to give the title compound (5.55 g., 0.0118 mole, 62%) in analytical purity.

1. concentrationThen the reaction mixture is concentrated in vacuo on a steam bath
2. dissolutionThe concentrate is dissolved in water
3. extractionextracted with ether
4. extractionextracted with ether
5. washThese ether extracts are washed with water until neutral,
6. dry with materialdried over anhydrous magnesium sulfate
7. concentrationconcentrated in vacuo