反应详情

A mixture of ethyl-m-[N,N-di(n-hexadecyl)aminomethyl]-thiobenzimidate dihydrochloride (1.074 g., 1.5 mmoles), p-anisidine (369 mg., 3.0 mmoles) and chloroform (10 ml.) was held at room temperature for sixteen hours. It was then diluted to 400 ml. with chloroform, washed with 1N HCl (2 × 50 ml.), dried (Na2SO4) and evaporated in vacuo to a foam. The foam was crystallized from 1,2-dimethoxyethane [868 mg., 73% yield, Rf 0.64 (4:1, benzene:ethanol on silicic acid), m.p.-forms a gel at 84°-86° C⟧

1. waitwas held at room temperature for sixteen hours
2. additionIt was then diluted to 400 ml
3. washwith chloroform, washed with 1N HCl (2 × 50 ml.)
4. dry with materialdried (Na2SO4)
5. customevaporated in vacuo to a foam
6. customThe foam was crystallized from 1,2-dimethoxyethane [868 mg
7. customat 84°-86° C