Sodium Hydroxide → HCID 70618826, compound

HRID 1833560Notes

Reaction equation

HRID 1833560 reaction equation
[N:1]1[C:6]([C:7]2[CH:11]=[C:10]([C:12]([O:14]CC)=[O:13])[O:9][N:8]=2)=[CH:5][CH:4]=[CH:3][C:2]=1[C:17]1[CH:21]=[C:20]([C:22]([O:24]CC)=[O:23])[O:19][N:18]=1.[OH-].[Na+]>O>[OH2:9].[N:1]1[C:2]([C:17]2[CH:21]=[C:20]([C:22]([OH:24])=[O:23])[O:19][N:18]=2)=[CH:3][CH:4]=[CH:5][C:6]=1[C:7]1[CH:11]=[C:10]([C:12]([OH:14])=[O:13])[O:9][N:8]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 21389805HCID 21389805, compound

Product 1

HCID 70618826HCID 70618826, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 2.5 g. (0.005 mole) of diethyl 3,3'-(2,6-pyridinediyl)di-5-isoxazolecarboxylate and 250 mg. of sodium hydroxide in 50 ml. of water is refluxed for ninety minutes. The reaction mixture is cooled to room temperature and the insoluble material removed by filtration. The filtrate is acidified with concentrated hydrochloric acid. The gelatinous precipitate is removed by filtration and washed with water. There is obtained 610 mg. of a tan solid (38%) melting at 284° (dec.).

Workup

  1. additionA mixture of 2.5 g
  2. customthe insoluble material removed by filtration
  3. customThe gelatinous precipitate is removed by filtration
  4. washwashed with water
  5. customThere is obtained 610 mg

Sources & evidence

ORD record
ord-99ba83b161a04d4296cda77777a3e9f5
Source dataset
uspto-grants-1978_01
Patent number
US04066769

Reaction notes

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