Diethyl Ether → HCID 178487596, compound

HRID 1833566Notes

Reaction equation

HRID 1833566 reaction equation
[N:1]#[N:2].[CH3:3][O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[CH:11]=[C:10]([S:15]([NH:18][C@H:19]([C:27]([OH:29])=O)[CH2:20][CH2:21][CH2:22][NH:23][C:24](=[NH:26])[NH2:25])(=[O:17])=[O:16])[CH:9]=[CH:8]2.C(OCC)C.S(Cl)([Cl:37])=O>>[N:1]#[N:2].[CH3:3][O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[CH:11]=[C:10]([S:15]([NH:18][C@H:19]([C:27]([Cl:37])=[O:29])[CH2:20][CH2:21][CH2:22][NH:23][C:24](=[NH:26])[NH2:25])(=[O:17])=[O:16])[CH:9]=[CH:8]2

Participants

4

Reactant 3

HCID 3283Diethyl EtherHCID 24386Thionyl ChlorideHCID 178487598HCID 178487598, compound

Product 1

HCID 178487596HCID 178487596, compound

Procedure

A suspension of 2.5 g of N2 -(6-methoxy-2-naphthylsulfonyl)-L-arginine in 20 ml of thionyl chloride was stirred for 2 hours at room temperature. Addition of cold dry ethyl ether resulted in a precipitate which was collected by filtration and washed several times with dry ethyl ether to give N2 -(6-methoxy-2-naphthylsulfonyl)-L-arginyl chloride.

Workup

  1. customresulted in a precipitate which
  2. filtrationwas collected by filtration
  3. washwashed several times with dry ethyl ether

Sources & evidence

ORD record
ord-19e9c130ac7548d89271a3b32566b3db
Source dataset
uspto-grants-1978_01
Patent number
US04066773

Reaction notes

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