Acetone → HCID 20333852, compound

HRID 1833689Notes

Reaction equation

HRID 1833689 reaction equation
[Br:1][C:2]1[O:3][C:4]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:5]=2[C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([CH2:13]Br)[CH:8]=1.[C-:20]#[N:21].[Na+].CC(C)=O>C(O)C>[Br:1][C:2]1[O:3][C:4]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:5]=2[C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([CH2:13][C:20]#[N:21])[CH:8]=1

Participants

5

Reactant 3

HCID 180AcetoneHCID 8929Sodium CyanideHCID 20333849HCID 20333849, compound2×

Product 1

HCID 20333852HCID 20333852, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The product of Step D, 2-bromo-3-(3-bromomethylphenyl)-5-chlorobenzofuran is reacted with sodium cyanide by heating to reflux in a solvent mixture of acetone and ethanol. Evaporation provides the desired product, 2-bromo-5-chloro-3-(3-cyanomethylphenyl)benzofuran.

Workup

  1. temperatureby heating
  2. customEvaporation

Sources & evidence

ORD record
ord-356599a44c194e118f57e544de60fee9
Source dataset
uspto-grants-1978_01
Patent number
US04066782

Reaction notes

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