Acetone → Ethyl 6-methylnicotinate

HRID 1833714Notes

Reaction equation

HRID 1833714 reaction equation
[CH3:1][C:2]1[CH:13]=[CH:12][C:5]([C:6](CC(=O)C)=[O:7])=[CH:4][N:3]=1.[CH3:14][C:15](C)=[O:16]>>[CH2:15]([O:16][C:6]([C:5]1[CH:12]=[CH:13][C:2]([CH3:1])=[N:3][CH:4]=1)=[O:7])[CH3:14]

Participants

3

Reactant 2

HCID 180AcetoneHCID 202128141-(6-Methylpyridin-3-yl)butane-1,3-dione

Product 1

HCID 281994Ethyl 6-methylnicotinate

Procedure

The 6-methylnicotinoyl-acetone which is mentioned as the starting substance in Example 6, can be obtained in a known manner from α-picoline-5-carboxylic acid ethyl ester and acetone, or from 5-acetyl-α-picoline (prepared in accordance with Angew. Ch. 67, page 398) and ethyl acetate:

Sources & evidence

ORD record
ord-7302fab9ec1b477bad43ebb018842f53
Source dataset
uspto-grants-1978_01
Patent number
US04066768

Reaction notes

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