HCID 21388822, compound → HCID 21388814, compound

HRID 1833733Notes

Reaction equation

HRID 1833733 reaction equation
Cl[C:2]1[C:7]([C:8]#[N:9])=[CH:6][N:5]=[C:4]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][CH2:18][CH3:19])=[CH:12][CH:11]=2)[N:3]=1>[Zn].O1CCOCC1>[C:8]([C:7]1[CH:2]=[N:3][C:4]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][CH2:18][CH3:19])=[CH:12][CH:11]=2)=[N:5][CH:6]=1)#[N:9]

Participants

4

Reactant 1

HCID 21388822HCID 21388822, compound

Product 1

HCID 21388814HCID 21388814, compound

Reagents, catalysts & solvents 2

HCID 23994ZincCatalystHCID 312751,4-DioxaneSolvent

Procedure

5.2 G. of 4-chloro-5-cyano-2-(4-n-butylphenyl)-pyrimidine are reacted in 230 ml. of 50% dioxane with 21.7 g. of pre-treated zinc dust and worked up after the reaction in a manner analogous to that described in Example 13. There is obtained 5-cyano-2-(4-n-butylphenyl)-pyrimidine as colorless crystals of melting point 108.6°-109.5° C., which on cooling are nematic (monotropic) at 101.5° C. The substance is identical with the compound obtained according to Example 8.

Workup

  1. customafter the reaction in a manner analogous to

Sources & evidence

ORD record
ord-adebcc1fe30c43afa5e542eb197212e7
Source dataset
uspto-grants-1978_01
Patent number
US04066570

Reaction notes

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