HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diazald → HCID 54204114, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diazald | HCID 6628 | — |
| Reactant | Diazomethane | HCID 9550 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Ethyl 12-(acetyloxy)-8-(chlorocarbonyl)heptadecanoate | HCID 20322197 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | HCID 131711019 | HCID 131711019 | — |
| Product | HCID 54204114 | HCID 54204114 | — |
Reaction Steps
Diazomethane (6 g., 0.143 mole) is generated via dropwise addition of a solution of Diazald ® (43 g.) in ether (400 ml.) over 45 minutes to a warm (65%), stirred solution of potassium hydroxide (12 g., 0.214 mole) in carbitol-water (7:2, 90 ml.). The resulting yellow, ethereal diazomethane distillate is cooled to 0° and treated with a solution of ethyl 8-chlorocarbonyl-12-acetoxyheptadecanoate (8.1 g., 0.02 mole) (Example 7, Step D), in ether (40 ml.) added over a period of 15 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04066692 |
| Source dataset | uspto-grants-1978_01 |
| ORD ID | ord-29749372288a4bb18aebe43bbc98fdd7 |
| Source note | uspto-grants-1978_01 |