Diisopropyl Ether → N-Methyl-5-(methylsulfanyl)-3-oxo-1,2,4-thiadiazole-2(3H)-carboxamide

Participants

Reaction Conditions

Reaction Steps

0.1 ml of triethylamine and 5 ml of methyl isocyanate were added to a solution of 7.5 g of 3-hydroxy-5-methylthio-1,2,4-thiadiazole in 50 ml of tetrahydrofuran and after stirring at 20° C for 3 hours, 25 ml of isopropyl ether were added. The mixture was vacuum filtered and the recovered crystals were washed, dried and crystallized from acetone to obtain 5.2 g of 2-(N-methylcarbamoyl)-5-methylthio-1,2,4-thiadiazole-3-one melting at 144° C.

Provenance & Evidence