Triethylamine → 5-(Ethylsulfanyl)-N-methyl-3-oxo-1,2,4-thiadiazole-2(3H)-carboxamide

Participants

Reaction Conditions

Reaction Steps

10.4 ml of triethylamine and 10 ml of methyl isocyanate were added to a solution of 20.3 g of 3-hydroxy-5-ethylthio-1,2,4-thiadiazole in 100 ml of tetrahydrofuran and the mixture was stirred at 20° C for 1 hour, cooled to -10° C and filtered. The product was crystallized from ethyl acetate to obtain 18 g of 2-(N-methylcarbamoyl)-5-ethylthio-1,2,4-thiadiazole-3-one melting at 131° C.

Provenance & Evidence