Triethylamine → N-Methyl-3-oxo-5-phenyl-1,2,4-thiadiazole-2(3H)-carboxamide

Participants

Reaction Conditions

Reaction Steps

0.5 ml of triethylamine and 10 ml of methyl isocyanate were added to a solution of 9 g of 3-hydroxy-5-phenyl-1,2,4-thiadiazole in 100 ml of tetrahydrofuran and the mixture was stirred at 20° C for an hour and then was vacuum filtered. The crystals recovered were crystallized from acetic acid to obtain 10 g of 2-(N-methylcarbamoyl)-5-phenyl-1,2,4-thiadiazole-3-one melting at 210° C.

Provenance & Evidence