Hydrochloric Acid → 2-[(2,6-Dichloropyridin-3-yl)oxy]propanoic acid

Participants

Role	Name	HCID	Charge
Reactant	Hydrochloric Acid	HCID 313	—
Reactant	Ethyl 2-[(2,6-dichloropyridin-3-yl)oxy]propanoate	HCID 12906172	—
Solvent	Sodium Hydroxide	HCID 14798	—
Product	2-[(2,6-Dichloropyridin-3-yl)oxy]propanoic acid	HCID 12906173	61.8%

Reaction Steps

105 g of 2-[(2,6-dichloro-3-pyridyl)oxy]propionic acid ethyl ester is refluxed with 550 ml of 1N sodium hydroxide solution for 1 hour. The pH value of the solution is brought to 1.5 with concentrated hydrochloric acid and the solution is filtered. Recrystallisation in ethanol/water yields 58 g of the above acid; m.p. 128°-131°;

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US04067725
Source dataset	uspto-grants-1978_01
ORD ID	ord-341c0d58a1c7458d85c7d48bdb13b66b
Source note	uspto-grants-1978_01