Dimethylformamide → 2-[(2,6-Dichloropyridin-3-yl)oxy]propanoyl chloride

Participants

Reaction Steps

23.6 g (0.1 mole) of 2-[(2,6-dichloro-3-pyridyl)oxy]-propionic acid, 150 ml of chloroform and 1.5 ml of dimethylformamide are heated with stirring to 55°, and in the course of 1 hour a solution of 18 g (0.15 mole) of thionyl chloride in 40 ml of chloroform is added dropwise. The reaction mixture is subsequently refluxed for 16 hours and is afterwards concentrated in vacuo. The product obtained is used directly for further reactions.

Provenance & Evidence