Dabco → HCID 54068375, compound

Participants

Reaction Steps

0.1 g of triethylenediamine, followed by 5.7 g (0.1 mol) of methyl isocyanate, was added to a solution of 16.4 g (0.1 mol) of 3-amino-phenylacetic acid methylamide in 100 ml of dioxane at room temperature. The mixture was stirred for a further 3 hours at 40° to 50° C. After cooling, the crystalline precipitate which had separated out was filtered off and dried. After recrystallization from ethanol, 19.5 g (88% of theory) of 3-(N'-methylureido)-phenylacetic acid methylamide of melting point 175°-177° C were obtained.

Provenance & Evidence