Dimethylcarbamoyl Chloride → HCID 57255687, compound

Participants

Reaction Steps

20.6 g (0.1 mol) of 3-amino-phenylacetic acid sec.-butylamide were dissolved in 100 ml of pyridine. 10.75 g (0.1 mol) of dimethylcarbamic acid chloride were added thereto. The mixture was stirred for a further 2 hours at room temperature and 2 hours at 50° to 60° C. The residue which remained after distilling off the pyridine under reduced pressure was stirred with very dilute hydrochloric acid, filtered off and then recrystallized from butyl acetate. 17 g (61.5% of theory) of 3-(N',N'-dimethylureido)-phenylacetic acid sec.-butylamide of melting point 170-171° C were obtained.

Provenance & Evidence