3-Benzylpyridazine → HCID 21387619, compound

HRID 1833836Notes

Reaction equation

HRID 1833836 reaction equation
C(C1N=NC([Cl:14])=CC=1)C1C=CC=CC=1.C(C1N=NC=CC=1)C1C=CC=CC=1.[CH3:28][C:29]1[CH:41]=[CH:40][CH:39]=[C:38]([CH3:42])[C:30]=1[CH2:31][C:32]1[N:33]=[N:34][CH:35]=[CH:36][CH:37]=1.[CH3:43][C:44]1[CH:56]=[C:55]([CH3:57])[CH:54]=[C:53]([CH3:58])[C:45]=1[CH2:46][C:47]1[N:48]=[N:49][CH:50]=[CH:51][CH:52]=1>>[Cl:14][C:35]1[N:34]=[N:33][C:32]([CH2:31][C:30]2[C:38]([CH3:42])=[CH:39][CH:40]=[CH:41][C:29]=2[CH3:28])=[CH:37][CH:36]=1.[Cl:14][C:50]1[N:49]=[N:48][C:47]([CH2:46][C:45]2[C:53]([CH3:58])=[CH:54][C:55]([CH3:57])=[CH:56][C:44]=2[CH3:43])=[CH:52][CH:51]=1

Participants

6

Reactant 4

HCID 5981493-BenzylpyridazineHCID 6404535HCID 6404535, compoundHCID 21387554HCID 21387554, compoundHCID 21387610HCID 21387610, compound

Product 2

HCID 21387619HCID 21387619, compoundHCID 21387690HCID 21387690, compound

Procedure

By proceeding in a similar manner but replacing the 3-chloro-6-(2-methylbenzyl)pyridazine by 6-benzyl-3-chloropyridazine (prepared as described in Netherlands Pat. No. 66-09504), 3-chloro-6-(2,6-dimethylbenzyl)pyridazine and 3-chloro-6-(2,4,6-trimethylbenzyl)pyridazine, there were prepared, respectively, 3-benzylpyridazine, m.p. 62°-64° C., 3-(2,6-dimethylbenzyl)pyridazine, m.p. 102°-103° C., and 3-(2,4,6-trimethylbenzyl)pyridazine, m.p. 110°-110.5° C.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-548a04ddf26c4c2c8e53296bc63d6617
Source dataset
uspto-grants-1978_01
Patent number
US04067723

Reaction notes

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