反应详情

Thionyl chloride (100 ml.) was added to a solution of 1-(2-fluorophenyl)ethanol [described by McCall, J.A.C.S. 74, 4809 (1952)] (105 g.) in dry chloroform (200 ml.). After the vigorous initial reaction had subsided, the solution was heated at reflux on a steam bath for 30 minutes. The excess of thionyl chloride was removed by repeated co-distillation with dry toluene and the residue was diluted with diethyl ether, washed with water (2 × 100 ml.), dried over sodium sulphate, filtered and evaporated to a yellow liquid, which was distilled to give 1-(2-fluorophenyl)ethyl chloride (73.2 g.), b.p. 70°-75° C./20 mm.Hg, as a pale yellow oil.

1. customAfter the vigorous initial reaction
2. temperaturethe solution was heated
3. temperatureat reflux on a steam bath for 30 minutes
4. customThe excess of thionyl chloride was removed
5. additionthe residue was diluted with diethyl ether
6. washwashed with water (2 × 100 ml.)
7. dry with materialdried over sodium sulphate
8. filtrationfiltered
9. customevaporated to a yellow liquid, which
10. distillationwas distilled