Methanol → Sodium Methoxide

Participants

Reaction Steps

A solution of sodium methoxide was prepared by the addition of sodium hydride (0.72 g.) to methanol (25 ml.). (±) 3-α-Chlorobenzylpyridazine (prepared as described in Example 2) (4.1 g.) was heated at reflux in this solution for 2 hours and the mixture was evaporated to dryness. The residue was dissolved in a mixture of diethyl ether and water and the ethereal layer was separated, dried over sodium sulphate and evaporated to give a brown oil. Distillation of this oil gave (±) 3-α-methoxybenzylpyridazine (1.8 g.), b.p. 140°-180° C./0.2-0.4 mm.Hg.

Provenance & Evidence