Diethyl chlorophosphate → 1-[Ethoxy(isothiocyanato)phosphoryl]oxyethane

Participants

Reaction Steps

One molar equivalent of diethoxyphosphoryl chloride of formula (II) is reacted neat with a 1.0 to 1.2 molar equivalent of anhydrous sodium-, potassium- or ammonium thiocyanate at a temperature range of 5° C to 30° C and, preferably, 15° C to 25° C for a period of time from 2 to 4 hours to yield diethoxyphosphinyl isothiocyanate of formula (III). The reaction is slightly exothermic, but is easily controlled by a cooling bath. The thus-obtained reaction mixture containing the isothiocyanate of formula (III) is used "as is" for the preparation of diethoxyphosphinyldithiocarbamate of formula (IV) as follows:

Provenance & Evidence