Water → HCID 86734035, compound

HRID 1833916Notes

Reaction equation

HRID 1833916 reaction equation
[CH:1]1([NH2:7])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.ClC([C:11]1[CH:24]=[CH:23][C:14]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:13][CH:12]=1)=O.[OH2:25].N1C=CC=C[CH:27]=1>>[CH:1]1([NH:7][C:27]([CH:16]([O:15][C:14]2[CH:13]=[CH:12][CH:11]=[CH:24][CH:23]=2)[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)=[O:25])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 4

HCID 962WaterHCID 1049PyridineHCID 7965CyclohexylamineHCID 37664104-Benzyloxybenzoylchloride

Product 1

HCID 86734035HCID 86734035, compound

Procedure

A mixture of cyclohexylamine (3.6g.; 0.036 mole) and 4-chlorocarbonylphenoxy phenyl methane (9.04 g.; 0.037 mole) in pyridine were heated under reflux for 6hr., then poured into water. The product was extracted into dichloromethane, the organic layer washed with dil. HCl and dried (anhyd. MgSO4). Removal of the drying agent and solvent yielded the crude product which was recrystallised from ethanol M.p. 183°-4°.

Workup

  1. temperaturewere heated
  2. temperatureunder reflux for 6hr
  3. extractionThe product was extracted into dichloromethane
  4. washthe organic layer washed with dil. HCl
  5. dry with materialdried (anhyd. MgSO4)
  6. customRemoval of the drying agent and solvent

Sources & evidence

ORD record
ord-0d0d84c6a1354216a29c4f904252cea4
Source dataset
uspto-grants-1978_01
Patent number
US04067892

Reaction notes

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