HCID 11030970, compound → HCID 70614840, compound

HRID 1833934Notes

Reaction equation

HRID 1833934 reaction equation
[CH:1]([NH:4][CH2:5][CH:6]([OH:20])[CH2:7][O:8][C:9]1[CH:10]=[C:11]([CH3:19])[CH:12]=[CH:13][C:14]=1[S:15]([CH3:18])(=[O:17])=[O:16])([CH3:3])[CH3:2].[CH2:21](N(C(C)C)CC1OC1)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.[Na].CS(C1C(C)=CC(O)=CC=1)(=O)=O>C(O)C>[CH2:21]([N:4]([CH:1]([CH3:3])[CH3:2])[CH2:5][CH:6]([OH:20])[CH2:7][O:8][C:9]1[CH:10]=[C:11]([CH3:19])[CH:12]=[CH:13][C:14]=1[S:15]([CH3:18])(=[O:16])=[O:17])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

5

Reactant 3

HCID 11030970HCID 11030970, compoundHCID 70614511HCID 70614511, compoundHCID 70614753HCID 70614753, compound

Product 1

HCID 70614840HCID 70614840, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A further modification of the procedure for preparing 1-(isopropylamino)-3-[4-(methylsulfonyl)-m-tolyloxy]-2-propanol employing an epihalohydrin derivative of Formula VII containing a hydrogenolyziable blocking group follows. 1-[(N-Benzyl)isopropylamino]-2,3-epoxypropane is reacted with 4-(methylsulfonyl)-m-cresol sodium salt in ethanol to provide 1-[(N-benzyl)isopropylamino]-3-[4-(methylsulfonyl)-m-tolyloxy]-2-propanol.

Workup

  1. additioncontaining

Sources & evidence

ORD record
ord-bc0987c86a1c4aa9b32f736944a293ca
Source dataset
uspto-grants-1978_01
Patent number
US04067904

Reaction notes

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