Phosphoric Acid → HCID 20327929, compound

HRID 1833997Notes

Reaction equation

HRID 1833997 reaction equation
[C:1]([O:5][C:6]([NH:8][CH:9]([C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([NH2:19])[CH:14]=1)[C:10]([OH:12])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].[O-:20][C:21]#[N:22].[K+].OP(O)(O)=O>O.C(O)(=O)C>[C:1]([O:5][C:6]([NH:8][CH:9]([C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([NH:19][C:21]([NH2:22])=[O:20])[CH:14]=1)[C:10]([OH:12])=[O:11])=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

6

Reactant 3

HCID 1004Phosphoric AcidHCID 11378442Potassium cyanateHCID 18622059alpha-t-Butoxycarbonylamino-m-aminophenylacetic acid

Product 1

HCID 20327929HCID 20327929, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent

Procedure

A solution of α-t-butoxycarbonylamino-m-aminophenylacetic acid (2.66 g, 0.01 mol) and potassium cyanate (0.81 g, 0.01 mol) in a mixture of water (35 ml) and acetic acid (2.5 ml) was heated at 56° for 3 hours. The solution was cooled, acidified with 40% H3PO4, and extracted with ethyl acetate. The dried extracts were evaporated to give the title product: mp 93°-95° (dec).

Workup

  1. temperaturewas heated at 56° for 3 hours
  2. temperatureThe solution was cooled
  3. extractionextracted with ethyl acetate
  4. customThe dried extracts were evaporated

Sources & evidence

ORD record
ord-df227068f55d43e3ad21daf0fc982300
Source dataset
uspto-grants-1978_01
Patent number
US04067976

Reaction notes

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