alpha-t-Butoxycarbonylamino-p-ureidophenylacetic acid → HCID 178477390, compound

HRID 1834014Notes

Reaction equation

HRID 1834014 reaction equation
[NH2:1][CH:2]1[C:20](=[O:21])[N:4]2[C:5]([C:17]([OH:19])=[O:18])=[C:6]([CH:9]([S:11][C:12]3[NH:16][N:15]=[N:14][N:13]=3)[CH3:10])[CH2:7][S:8][C@H:3]12.C(OC([NH:29][CH:30]([C:34]1[CH:39]=[CH:38][C:37]([NH:40][C:41]([NH2:43])=[O:42])=[CH:36][CH:35]=1)[C:31](O)=[O:32])=O)(C)(C)C>>[CH3:10][CH:9]([S:11][C:12]1[NH:13][N:14]=[N:15][N:16]=1)[C:6]1[CH2:7][S:8][C@@H:3]2[CH:2]([NH:1][C:31](=[O:32])[CH:30]([C:34]3[CH:35]=[CH:36][C:37]([NH:40][C:41]([NH2:43])=[O:42])=[CH:38][CH:39]=3)[NH2:29])[C:20](=[O:21])[N:4]2[C:5]=1[C:17]([OH:19])=[O:18]

Participants

3

Reactant 2

HCID 20327935alpha-t-Butoxycarbonylamino-p-ureidophenylacetic acidHCID 1784773817-Amino-3-(1-methyl-1H-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid

Product 1

HCID 178477390HCID 178477390, compound

Procedure

When 7 -amino-3-(1-methyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid (3.28 g, 0.01 mol) was acylated with the product of Example 1 (3.1 g, 0.01 mol) according to the procedure of Example 2, the title compound was obtained: mp > 300°.

Sources & evidence

ORD record
ord-5c4cb5a47c374d4985faf5782f07ae1c
Source dataset
uspto-grants-1978_01
Patent number
US04067978

Reaction notes

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