HCID 20195970, compound → 1-Cyano-2-methylamino-2-[4-(3-chloro-2-pyridyl)butylamino]-ethylene

HRID 1834030Notes

Reaction equation

HRID 1834030 reaction equation
[Cl:1][C:2]1[C:3]([CH2:8][CH2:9][CH2:10][CH2:11][NH2:12])=[N:4][CH:5]=[CH:6][CH:7]=1.[C:13]([CH:15]=[C:16](OCC)[NH:17][CH3:18])#[N:14]>>[C:13]([CH:15]=[C:16]([NH:17][CH3:18])[NH:12][CH2:11][CH2:10][CH2:9][CH2:8][C:3]1[C:2]([Cl:1])=[CH:7][CH:6]=[CH:5][N:4]=1)#[N:14]

Participants

3

Reactant 2

HCID 20195970HCID 20195970, compoundHCID 736832021-Cyano-2-ethoxy-2-methylaminoethylene

Product 1

HCID 706195031-Cyano-2-methylamino-2-[4-(3-chloro-2-pyridyl)butylamino]-ethylene

Procedure

3-Chloro-2-(4-aminobutyl)pyridine is added to a solution of 1-cyano-2-ethoxy-2-methylaminoethylene and stirred at 100° for 5 hours. Chromatographic purification of the reaction mixture yields the title compound.

Workup

  1. customChromatographic purification of the reaction mixture

Sources & evidence

ORD record
ord-4487c046698c45b898278ab6fb4316ea
Source dataset
uspto-grants-1978_01
Patent number
US04067984

Reaction notes

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