HuagongsheHuagongshe Chemistry Print Report · For research reference only
O-Xylene → Carboprost tromethamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | O-Xylene | HCID 7237 | — |
| Reactant | Dinoprost | HCID 5280363 | — |
| Product | Carboprost tromethamine | HCID 35023177 | — |
Reaction Steps
Following the procedure of example 1 but substituting (15S) 15-methyl PGF2α for PGF2α and extending the reaction time in refluxing xylene from 24 hours to 48 hours there is produced crude (15S)-15-methyl PGF2α, 1,15-lactone. The crude lactone is purified by repeated chromatography and, further, if desired, by TLC purification to afford in low yield (15S)-15-methyl-PGF2α, 1,15-lactone in essentially pure form.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04067991 |
| Source dataset | uspto-grants-1978_01 |
| ORD ID | ord-067f32b7c3f248c9a05693f10e48a45e |
| Source note | uspto-grants-1978_01 |