Dichloromethane → Cephaloglycin

Participants

Reaction Steps

After stirring 35 ml. of a methylene chloride solution containing 2.12 g. of cephaloglycin monohydrate, 1.5 g. of anhydrous magnesium sulfate, and 1.4 ml. of triethylamine for one hour at room temperature, magnesium sulfate was filtered off to provide a solution of triethylamine salt of cephaloglycin. After cooling the solution to -25° C., 816 mg. of 2-imidazolidone-1-carboxylic acid chloride and further 0.3 ml. of triethylamine were added thereto.

Provenance & Evidence