HCID 70561582, compound → HCID 70563004, compound

HRID 1834140Notes

Reaction equation

HRID 1834140 reaction equation
[NH2:1][C@H:2]([C:10]([NH:12][C@H:13]([C:15]([N:17]([C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][C:20]=1[C:26](=[O:33])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH3:18])=[O:16])[CH3:14])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>CO>[ClH:25].[NH2:1][C@H:2]([C:10]([NH:12][C@H:13]([C:15]([N:17]([C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][C:20]=1[C:26](=[O:33])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH3:18])=[O:16])[CH3:14])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

3

Reactant 1

HCID 70561582HCID 70561582, compound

Product 1

HCID 70563004HCID 70563004, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.5 g of L-phenylalanyl-N-(2-benzoyl-4-chlorophenyl)-N-methyl-L-alaninamide was dissolved in a minimum amount of methanol at room temperature and treated, by titration, with an exact equivalent of 1-N-hydrochloric acid. The solvent was removed from the resulting solution by evaporation in vacuo at room temperature and finally by lyophilisation to give, in quantitative yield, L-phenylalanyl-N-(2-benzoyl-4-chlorophenyl)-N-methyl-L-alaninamide hydrochloride as a white hygroscopic light-sensitive amorphous powder of melting point 130° -140° C (slow decomposition): [α]D20 = -40.0° (c = 1 in water).

Workup

  1. customThe solvent was removed from the resulting solution by evaporation in vacuo at room temperature and finally by lyophilisation

Sources & evidence

ORD record
ord-fa805c7dd6b148fba60969c6996cc460
Source dataset
uspto-grants-1978_01
Patent number
US04069229

Reaction notes

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