Potassium Carbonate → HCID 20374289, compound

Participants

Reaction Steps

3 Parts of 3,3,3-triphenylpropionic acid are refluxed with 1 part by volume of thionyl chloride in 25 parts by volume of benzene for about 2 hours. The reaction mixture is then cooled and poured into a mixture of 2.2 parts of 4-phenylisonipecotonitrile hydrochloride, 4.1 parts of potassium carbonate in 20 parts by volume of water and 20 parts by volume of benzene. This reacton mixture is stirred under nitrogen while cooling in an ice bath, and then methylene chloride and water are added to the reaction mixture and the 2-phase system is filtered from the solid which forms. The organic layer is separated, washed with water and with saturated sodium sulfate and dried. The solvent is evaporated to leave an oily residue which is crystallized from ether to afford 4-phenyl-1-(3,3,3-triphenyl-propionyl)isonipecotonitrile melting at about 188.5°-190.5° C. This crystalline product is identical to the aforementioned solid and is represented by the following structural formula ##STR11##

Provenance & Evidence