Hydrochloric Acid → HCID 20374242, compound

Participants

Reaction Steps

A solution is prepared from 5.9 parts of the nitrile obtained in the preceding paragraph and 134 parts of methylene chloride. This solution is saturated with hydrogen chloride gas at below 10° C. and 5.1 parts of thionyl chloride is added. The mixture is refluxed for 1 hour and then cooled and volatile material is removed under reduced pressure. The residue is dissolved in 88 parts of benzene, and the solution evaporated under reduced pressure. The residue is then crystallized from a mixture of ethanol and ether to give 1-(2-chloroethyl)-4-phenylisonipecotonitrile hydrochloride.

Provenance & Evidence