Tetrahydrofuran → HCID 20374254, compound

Participants

Reaction Steps

A mixture of 3 parts of 4-phenyl-1-(3,3,3-triphenylpropionyl)isonipecotonitrile and 3 parts of lithium aluminum hydride in 150 parts by volume of tetrahydrofuran is refluxed overnight and then the excess of lithium aluminum hydride is decomposed by the successive addition of 1 part by volume of water, 1 part by volume of 15% sodium hydroxide and 3 parts by volume of water. The mixture is then filtered and the solvent evaporated to afford, as an oil, 4-aminomethyl-4-phenyl-1-(3,3,3-triphenylpropyl)piperidine. This compound is represented by the following structural formula ##STR13##

Provenance & Evidence