Sodium Hydroxide → HCID 23699410, compound

HRID 1834171Notes

Reaction equation

HRID 1834171 reaction equation
[C:1]([NH:4][C:5]1[C:6]([I:35])=[C:7]([C:16]([NH:18][C:19]([CH2:30][O:31][C:32](=[O:34])[CH3:33])([CH2:25][O:26][C:27](=[O:29])[CH3:28])[CH2:20][O:21][C:22](=[O:24])[CH3:23])=[O:17])[C:8]([I:15])=[C:9]([C:13]=1[I:14])[C:10]([OH:12])=[O:11])(=[O:3])[CH3:2].[OH-].[Na+:37]>O>[C:1]([NH:4][C:5]1[C:6]([I:35])=[C:7]([C:16]([NH:18][C:19]([CH2:25][O:26][C:27](=[O:29])[CH3:28])([CH2:30][O:31][C:32](=[O:34])[CH3:33])[CH2:20][O:21][C:22](=[O:24])[CH3:23])=[O:17])[C:8]([I:15])=[C:9]([C:13]=1[I:14])[C:10]([O-:12])=[O:11])(=[O:3])[CH3:2].[Na+:37]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 22749364HCID 22749364, compound

Product 1

HCID 23699410HCID 23699410, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

A stirred slurry of 5-acetamido-2,4,6-triiodo-N-[tris(acetoxymethyl)methyl]isophthalamic acid (4.15 g., 5 mol.) in water (20 ml.) was carefully neutralized by dropwise addition of 1 N sodium hydroxide solution (5.00 ml.) so that the pH of the solution never exceeded 7.00. The resulting clear solution (pH 6.98) was concentrated under reduced pressure at room temperature (25°, 20 mm. to 0.1 mm.) and dried overnight in vacuo (0.1 mm.) to yield the salt indicated in the caption as a white powder (4.2 g.). The solubility of this powder in water is greater than or equal to 100% (wt/vol).

Workup

  1. concentrationThe resulting clear solution (pH 6.98) was concentrated under reduced pressure at room temperature (25°, 20 mm. to 0.1 mm.)
  2. customdried overnight in vacuo (0.1 mm.)
  3. customto yield the salt

Sources & evidence

ORD record
ord-0f208ecd19994b2594a6467eadacba71
Source dataset
uspto-grants-1978_01
Patent number
US04069250

Reaction notes

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