HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → Methyl N-methyl-5-nitro-N-[tris(hydroxymethyl)methyl]isophthalamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 10164823 | HCID 10164823 | — |
| Reactant | Methyl 2-(chlorocarbonyl)-4-nitrobenzoate | HCID 13221842 | — |
| Product | Methyl N-methyl-5-nitro-N-[tris(hydroxymethyl)methyl]isophthalamate | HCID 22749370 | — |
Reaction Steps
Methoxy-carbonyl-5-nitrobenzoyl chloride [G. B. Hoey, et al., J. Med. Chem, 6, 24 (1963)] is added to a cold stirred slurry of N-methyl-tris(hydroxymethyl)-methylamine and potassium carbonate in dimethylformamide to form a solution of N-methyl-5-nitro-N-[tris(hydroxymethyl)methyl]isophthalamic acid, methyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04069250 |
| Source dataset | uspto-grants-1978_01 |
| ORD ID | ord-216411be9e1a413dbd236d88c5546600 |
| Source note | uspto-grants-1978_01 |