Sodium Hydroxide → HCID 23699408, compound

HRID 1834175Notes

Reaction equation

HRID 1834175 reaction equation
[I:1][C:2]1[C:10]([C:11]([NH:13][C:14]([CH2:19][OH:20])([CH2:17][OH:18])[CH2:15][OH:16])=[O:12])=[C:9]([I:21])[C:8]([NH:22][C:23](=[O:27])[CH2:24][O:25][CH3:26])=[C:7]([I:28])[C:3]=1[C:4]([OH:6])=[O:5].[OH-].[Na+:30]>>[I:1][C:2]1[C:10]([C:11]([NH:13][C:14]([CH2:15][OH:16])([CH2:19][OH:20])[CH2:17][OH:18])=[O:12])=[C:9]([I:21])[C:8]([NH:22][C:23](=[O:27])[CH2:24][O:25][CH3:26])=[C:7]([I:28])[C:3]=1[C:4]([O-:6])=[O:5].[Na+:30]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 22749355HCID 22749355, compound

Product 1

HCID 23699408HCID 23699408, compound

Procedure

2,4,6-Triiodo-5-methoxyacetamido-N-[tris(hydroxymethyl)methyl] isophthalamic acid (2.03 g.) was dissolved in a stoichiometric quantity of 0.1032 N NaOH. The solution was evaporated under reduced pressure at 60° C. and the residual sodium salt was dried at 45° C. overnight. The solubility of this sodium salt in water at 25° C. is approximately 67.4% (w/v). The following examples illustrate the use of certain compounds of the invention in the preparation of X-ray contrast media.

Workup

  1. customThe solution was evaporated under reduced pressure at 60° C.
  2. dry with materialthe residual sodium salt was dried at 45° C. overnight
  3. customat 25° C.
  4. customin the preparation of X-ray contrast media

Sources & evidence

ORD record
ord-990288c644f6407a9109069e698bdd6c
Source dataset
uspto-grants-1978_01
Patent number
US04069250

Reaction notes

Loading…