Ethyl Acetate → HCID 21386605, compound

Participants

Reaction Steps

A solution of 240 mg of m-chloroperbenzoic acid in 10 ml of dioxan was introduced, while stirring, into a solution of 0.54 g of 3-carbomethoxyamino-7-(3-trifluoromethyl-phenylsulfonyloxy)-1H-2,1,4-benzothiadiazine in 50 ml of dioxan. The mixture was stirred for 15 minutes, then it was diluted with 100 ml of water, neutralized with sodium carbonate solution, and subsequently the whole was shaken with ethyl acetate. After washing out the ester extract with sodium chloride solution, the ester solution was strongly concentrated, and the separated 3-carbomethoxyamino-7-(3-trifluoromethyl-phenylsulfonyloxy)-1H-2,1,4-benzothiadiazine-S-oxide was isolated by way of filtration. The yield was 120 mg.

Provenance & Evidence