Benzoyl chloride → HCID 21386590, compound

Participants

Reaction Steps

1 Milliliter of benzoyl chloride was added dropwise, while stirring and cooling with an ice mixture, to a solution of 1.4 g of 3-carbomethoxyamino-7-(3-trifluoromethyl-phenylsulfonyloxy)-1H-2,1,4-benzothiadiazine-S-oxide in 20 ml of pyridine. After the mixture has been stirred for 2 hours at 0° C, 1 ml of benzoyl chloride was added once more. After another hour of stirring at 0° C, the reaction mixture was diluted with water. It was then shaken with ethyl acetate, and the extract was washed with saturated sodium chloride solution. After evaporation of the solvent, the residue was isolated by trituration with methanol and filtration. 1-Benzoyl-3-carbomethoxyamino-7-(3-trifluoromethyl-phenylsulfonyloxy)-1H-2,1,4-benzothiadiazine-S-oxide was obtained in a yield of 1.1 g.

Provenance & Evidence