Methyl Isocyanate → N-Methyl-N'-[2-(3-pyridazinylmethylamino)ethyl]urea

HRID 1834270Notes

Reaction equation

[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][NH:8][CH2:9][CH2:10][NH2:11])[N:2]=1.[CH3:12][N:13]=[C:14]=[O:15]>>[CH3:12][NH:13][C:14]([NH:11][CH2:10][CH2:9][NH:8][CH2:7][C:3]1[N:2]=[N:1][CH:6]=[CH:5][CH:4]=1)=[O:15]

Participants

Reactant 2

HCID 12228Methyl Isocyanate

HCID 21698444N-(3-pyridazinylmethyl)ethylenediamine

Product 1

HCID 20557601N-Methyl-N'-[2-(3-pyridazinylmethylamino)ethyl]urea

Procedure

Reacting N-(3-pyridazinylmethyl)ethylenediamine with methyl isocyanate by the procedure of Example 24, then concentrating and separating the residue by column chromatography gives the title compound.

Workup

concentrationconcentrating
customseparating the residue by column chromatography

Sources & evidence

ORD record: ord-61ab768321084202bfdf4cd6ce44e7d3
Source dataset: uspto-grants-1978_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04069327

Reaction notes

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