p-Toluenesulfonic acid → HCID 357800, compound

Participants

Reaction Steps

To a solution of 66 g. of ethyl 6-hydroxyhexanoate in 400 ml. of methylene chloride were added 1 g. of p-toluenesulphonic acid and 45 g. of 2,3-dihydropyran and the mixture was stirred at 25° C. for 20 minutes. The reaction mixture was then washed with an aqueous solution of sodium bicarbonate, dried and concentrated. The residue was distilled in vacuo to obtain 77 g. of the title compound having the following physical characteristics:-

Provenance & Evidence