HCID 54276494, compound → HCID 53990871, compound

HRID 1834367Notes

Reaction equation

HRID 1834367 reaction equation
[CH2:1]([O:3][C:4](=[O:25])[C:5]1[C:10]([NH:11][CH2:12][CH2:13][CH2:14][CH3:15])=[C:9]([N+:16]([O-])=O)[C:8]([NH:19][CH2:20][CH:21]([CH3:23])[CH3:22])=[N:7][C:6]=1[CH3:24])[CH3:2].[H][H]>[Pd].C(O)CCC>[CH2:1]([O:3][C:4](=[O:25])[C:5]1[C:10]([NH:11][CH2:12][CH2:13][CH2:14][CH3:15])=[C:9]([NH2:16])[C:8]([NH:19][CH2:20][CH:21]([CH3:23])[CH3:22])=[N:7][C:6]=1[CH3:24])[CH3:2]

Participants

5

Reactant 2

HCID 54276494HCID 54276494, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 53990871HCID 53990871, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 2631-ButanolSolvent

Procedure

17.6 g. of butylamino-6-(2-methylpropyl)amino-2-methyl-5-nitronicotinic acid ethyl ester (0.05 mol.) are dissolved in 100 ml. of butyl alcohol. 200 mg. of palladium on charcoal are added and the mixture is hydrogenated at 80° until the theoretical amount of hydrogen has been absorbed. The catalyst is filtered off and the mixture evaporated to dryness. The resulting oil, 5-amino-4-butylamino-6-(2-methylpropyl)amino-2-methylnicotinic acid ethyl ester, is used without further purification.

Workup

  1. customhas been absorbed
  2. filtrationThe catalyst is filtered off
  3. customthe mixture evaporated to dryness
  4. customThe resulting oil, 5-amino-4-butylamino-6-(2-methylpropyl)amino-2-methylnicotinic acid ethyl ester, is used without further purification

Sources & evidence

ORD record
ord-6aa233d2845941f6b54d3217411af04b
Source dataset
uspto-grants-1978_01
Patent number
US04070362

Reaction notes

Loading…