Phosphorus sulfide (P2S5) → 7-chloro-5-phenyl-1H-1,5-benzodiazepin-4-one-2-thione

HRID 1834373Notes

Reaction equation

HRID 1834373 reaction equation
[Cl:1][C:2]1[CH:20]=[CH:19][C:5]2[NH:6][C:7](=O)[CH2:8][C:9](=[O:17])[N:10]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[C:4]=2[CH:3]=1.P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=[S:22]>N1C=CC=CC=1>[Cl:1][C:2]1[CH:20]=[CH:19][C:5]2[NH:6][C:7](=[S:22])[CH2:8][C:9](=[O:17])[N:10]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 14817Phosphorus sulfide (P2S5)HCID 89657Desmethylclobazam

Product 1

HCID 122643197-chloro-5-phenyl-1H-1,5-benzodiazepin-4-one-2-thione

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A solution of 28.6 g of 7-chloro-5-phenyl-1H-1,5-benzodiazepine-2,4-dione and 23.3 g of phosphorus pentasulfide in 250 ml of pyridine is refluxed, with stirring, for 40 minutes under argon. The solvent is evaporated in vacuo.

Workup

  1. customThe solvent is evaporated in vacuo

Sources & evidence

ORD record
ord-5d0944d3682e46d9881fdbcdae387029
Source dataset
uspto-grants-1978_01
Patent number
US04070355

Reaction notes

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