Acetic Anhydride → HCID 68117748, compound

HRID 1834377Notes

Reaction equation

HRID 1834377 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12](=[O:15])[N:13]=[N:14][C:10]3=[CH:9][C:8](=[O:16])[N:7]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:6]=2[CH:23]=1.[C:24](OC(=O)C)(=[O:26])[CH3:25]>N1C=CC=CC=1>[C:24]([NH:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12](=[O:15])[N:13]=[N:14][C:10]3=[CH:9][C:8](=[O:16])[N:7]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:6]=2[CH:23]=1)(=[O:26])[CH3:25]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 20373036HCID 20373036, compound

Product 1

HCID 68117748HCID 68117748, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

2.91 g of 8-amino-6-phenyl-1H-s-triazolo[4,3-a][1,5]benzodiazepine-1,5-dione and 1.02 g of acetic anhydride in 50 ml pyridine is stirred for 12 hours then refluxed for 30 minutes. The reaction is evaporated; the residue is taken up in chloroform, washed with dilute aqueous sodium bicarbonate, with water and dried. The solvent is evaporated to give the title compound.

Workup

  1. temperaturethen refluxed for 30 minutes
  2. customThe reaction is evaporated
  3. washwashed with dilute aqueous sodium bicarbonate, with water
  4. customdried
  5. customThe solvent is evaporated

Sources & evidence

ORD record
ord-4fd62fb8dc6e4dc89e33b53409597e25
Source dataset
uspto-grants-1978_01
Patent number
US04070355

Reaction notes

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