Phosphorus oxychloride → HCID 20373304, compound

Participants

Reaction Steps

A stirred mixture of 5-(4-cyanophenyl)-2-furaldehyde oxime (16 g, 0.075 mole) and benzene (400 ml) was heated to reflux and a solution of POCl3 (4 ml) in benzene (20 ml) was added dropwise over 15 minutes. The mixture was refluxed for 11/2 hours and filtered while hot. The filtrate was washed with 5% NaHCO3 (500 ml), H2O (500 ml), dried over MgSO4 and Darco and filtered. The filtrate was stripped of solvent under reduced pressure to yield 10 g (69%) of 5-(4-cyanophenyl)-2-furonitrile.

Provenance & Evidence