HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propanal → 2,4-Dimethyl-3-acetyl-5-n-Propyl-pyrrole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propanal | HCID 527 | — |
| Reactant | Ketone, 2,4-dimethylpyrrol-3-yl methyl | HCID 15163 | — |
| Reactant | Hydrogen iodide | HCID 24841 | — |
| Reactant | Ethyl 3,4,5-trimethyl-1H-pyrrole-2-carboxylate | HCID 137479 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 2,4-Dimethyl-3-acetyl-5-n-Propyl-pyrrole | HCID 20373205 | 59% |
Reaction Steps
2,4-Dimethyl-3-acetyl-pyrrole (1.02 g), acetic acid (15 ml), aqueous hydriodic acid (25ml) and propionaldehyde (1.74g), were stirred at 25° C. three hours under nitrogen. The work up was the same as that of 2,3,4-trimethyl-5-carbethoxy-pyrrole in Example 4 except that 2 × 50 ml ether were used. Recrystallization from benzene gave the product 0.786 g (59%) m.p. 157°-158°C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04070366 |
| Source dataset | uspto-grants-1978_01 |
| ORD ID | ord-d080107f1784485ba4badc191f6a9788 |
| Source note | uspto-grants-1978_01 |