Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Ketone, 2,4-dimethylpyrrol-3-yl methyl | HCID 15163 | — |
| Reactant | Hydrogen iodide | HCID 24841 | — |
| Reactant | Phosphinic Acid | HCID 4124402 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Cyclohexanone | HCID 7967 | — |
| Product | HCID 20373177 | HCID 20373177 | — |
Reaction Steps
A solution of 10 ml of aqueous hydriodic acid, 10 ml of acetic anhydride and 2 ml of 50% hypophosphorous acid was stirred magnetically at 40° C. while 548 mg of 2,4-dimethyl-3-acetyl-pyrrole were dissolved in it, 0.5 ml of cyclohexanone was then added, and an additional 0.5 ml of cyclohexanone was added after a few minutes'. The solution was stirred at 40° C. for 11/2 hrs. then poured into water. The crude product which separated, m.p. 186°-188° C. was recrystallized from ethanol as colourless rhombic prisms (82%), m.p. 188.5°-189° C. after changing to flat prisms above 153° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04070366 |
|---|
| Source dataset | uspto-grants-1978_01 |
|---|
| ORD ID | ord-a3c275d2ee4141f3a9c1acda8828e7c2 |
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| Source note | uspto-grants-1978_01 |
|---|
