HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 2,3,4,5-Tetramethylpyrrole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Hydrogen iodide | HCID 24841 | — |
| Reactant | Diethyl 2,4-dimethylpyrrole-3,5-dicarboxylate | HCID 75526 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2,3,4,5-Tetramethylpyrrole | HCID 70484 | — |
Reaction Steps
2,4-Dimethyl-3,5-dicarbethoxy-pyrrole (2.4 g), acetic acid (35 ml), aq. hydriodic acid (35 ml) and paraformaldehyde (1.2 g) were heated at 100° C. for 4 hours under a stream of nitrogen. The crude product was obtained as in Example 5 then distilled (15 mm, 65° C.) to yield 0.44 g (36%), m.p. 107°-109°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04070366 |
| Source dataset | uspto-grants-1978_01 |
| ORD ID | ord-0baf3f5bc1ad4bf69c54939ae6114f89 |
| Source note | uspto-grants-1978_01 |