Isobutyraldehyde → HCID 20373134, compound

HRID 1834428Notes

Reaction equation

HRID 1834428 reaction equation
[CH3:1][C:2]1[NH:3][C:4]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:5][C:6]=1[CH3:7].[CH:13](=O)[CH:14]([CH3:16])[CH3:15]>O>[CH3:1][C:2]1[NH:3][C:4]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[C:5]([CH2:13][CH:14]([CH3:16])[CH3:15])[C:6]=1[CH3:7]

Participants

4

Reactant 2

HCID 6561IsobutyraldehydeHCID 137478Ethyl 4,5-dimethyl-1H-pyrrole-2-carboxylate

Product 1

HCID 20373134HCID 20373134, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

As in Example 32 but using 2,3-dimethyl-5-carbethoxy-pyrrole and isobutyraldehyde, pouring the mixture into water after 3 hrs and extracting the product from the alkaline mixture with ether. It was distilled (70°, 1 × 10-4 mm) and crystallized from pentane as colourless prisms (45%), m.p. 109°-111°. Anal. Calc. for C13H21NO2 : C, 69.92; H, 9.48; N, 6.27. Found: C, 70.23; H, 9.79; N, 6.27.

Workup

  1. extractionextracting the product from the alkaline mixture with ether
  2. distillationIt was distilled (70°, 1 × 10-4 mm)
  3. customcrystallized from pentane as colourless prisms (45%), m.p. 109°-111°

Sources & evidence

ORD record
ord-fd0e0fc7659242019b034f68204c06c9
Source dataset
uspto-grants-1978_01
Patent number
US04070366

Reaction notes

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