Formaldehyde → 2,4,5-Trimethyl-3-isobutyl pyrrole

HRID 1834459Notes

Reaction equation

[CH3:1][C:2]1[NH:3][C:4]([C:12](OCC)=O)=[C:5]([CH3:11])[C:6]=1[CH2:7][CH:8]([CH3:10])[CH3:9].C=O>>[CH3:1][C:2]1[NH:3][C:4]([CH3:12])=[C:5]([CH3:11])[C:6]=1[CH2:7][CH:8]([CH3:10])[CH3:9]

Participants

Reactant 2

HCID 712Formaldehyde

HCID 678569ethyl 4-isobutyl-3,5-dimethyl-1H-pyrrole-2-carboxylate

Product 1

HCID 203731332,4,5-Trimethyl-3-isobutyl pyrrole

Procedure

2,4-Dimethyl-3-isobutyl-5-carbethoxy-pyrrole was reductively alkylated with paraformaldehyde to yield 2,4,5-trimethyl-3-isobutyl-pyrrole. ##STR98##

Sources & evidence

ORD record: ord-694ed91e87b844e7af25ac93530c8de0
Source dataset: uspto-grants-1978_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04070366

Reaction notes

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