Benzoyl chloride → 8-Benzoyl-2-methyl-4-phenyl-4H-pyrazolo[1,5-a]pyrazolo-[4',3':5,6]pyrido[3,4-e]pyrimidin-5(8H)-one

HRID 1834522Notes

Reaction equation

HRID 1834522 reaction equation
[CH3:1][C:2]1[CH:24]=[C:5]2[N:6]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[C:7](=[O:17])[C:8]3[CH:13]=[N:12][C:11]4[NH:14][N:15]=[CH:16][C:10]=4[C:9]=3[N:4]2[N:3]=1.[C:25](Cl)(=[O:32])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>N1C=CC=CC=1>[C:25]([N:14]1[C:11]2[N:12]=[CH:13][C:8]3[C:7](=[O:17])[N:6]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[C:5]4[N:4]([N:3]=[C:2]([CH3:1])[CH:24]=4)[C:9]=3[C:10]=2[CH:16]=[N:15]1)(=[O:32])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

Participants

4

Reactant 2

HCID 7412Benzoyl chlorideHCID 227574532-Methyl-4-phenyl-4H-pyrazolo[1,5-a]pyrazolo[4',3':5,6]pyrido[3,4-e]pyrimidin-5(8H)-one

Product 1

HCID 227574668-Benzoyl-2-methyl-4-phenyl-4H-pyrazolo[1,5-a]pyrazolo-[4',3':5,6]pyrido[3,4-e]pyrimidin-5(8H)-one

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

0.01 mol. of 2-methyl-4-phenyl-4H-pyrazolo[1,5-a]-pyrazolo[4',3':5,6]pyrido[3,4-e]pyrimidin-5(8H)-one and 0.02 mol. of benzoyl chloride are stirred overnight in 50 ml. of dry pyridine at room temperature. On addition of 50 ml. of water, 8-benzoyl-2-methyl-4-phenyl-4H-pyrazolo-[1,5-a]pyrazolo[4',3':5,6]pyrido[3,4-e]pyrimidin-5(8H)-one is filtered off.

Workup

  1. customat room temperature
  2. additionOn addition of 50 ml
  3. filtrationof water, 8-benzoyl-2-methyl-4-phenyl-4H-pyrazolo-[1,5-a]pyrazolo[4',3':5,6]pyrido[3,4-e]pyrimidin-5(8H)-one is filtered off

Sources & evidence

ORD record
ord-f0605e3848bb4f0ebd1f3f1f66ce3931
Source dataset
uspto-grants-1978_01
Patent number
US04070466

Reaction notes

Loading…